Microdosing Ketamine: Unlocking Sub-Perceptual Benefits for Mood and Cognition
Introduction Ketamine, a dissociative anesthetic, has garnered significant attention for its potential therapeutic applications beyond its established role in anesthesia and pain management. While traditionally used at higher doses to treat severe depression and other conditions, recent research has explored the potential benefits of microdosing ketamine—administering sub-perceptual doses that do not induce noticeable psychoactive effects. This approach aims to leverage ketamine's purported neurotrophic and neuroplasticity-enhancing properties to improve mood, cognition, and overall well-being, without the associated side effects of higher doses. However, it's crucial to approach this topic with caution and acknowledge the limited and often preliminary nature of the existing research. The use of microdosing ketamine remains largely outside the purview of established medical practice, and its efficacy and safety are still under investigation. This article serves as an in...